Search results for "Blistering disease"

showing 3 items of 3 documents

Reciprocal altered expression of E-cadherin and P-cadherin in mucous membrane pemphigoid.

2011

E- and P- cadherins are involved in the selective adhesion of epidermal cells. To gain insight into the role of cadherins on the acantholysis of keratinocytes and further investigate the pathogenesis of Mucous Membrane Pemphigoid, we examined the expression of P-cadherin and E-cadherin, in normal human oral mucosa, lesional and peri-lesional mucosa in MMP. Twenty-nine samples from paraffin-embedded specimens of MMP were used for the study. Five specimens of healthy oral mucosa were evaluated as control group. To evaluate the E- and P-Cadherin expression, a mean percentage of positive cells was determined from the percentage of positive cells derived from the analysis of 100 cells in ten ra…

AdultMalePathologymedicine.medical_specialtyPemphigoidmucous pemphigoidBlistering disease; E-cadherin; Mucous Membrane Pemphigoid; P-cadherin;Blistering diseaseImmunologySettore MED/50 - Scienze Tecniche Mediche ApplicatePemphigoid Benign Mucous MembraneMucous Membrane PemphigoidHuman skinBiologyP-cadherinPathogenesisDownregulation and upregulationSettore MED/28 - Malattie OdontostomatologichemedicineImmunology and AllergyHumansOral mucosaAgedPharmacologyAged 80 and overCadherinAcantholysismucous pemphigoid; cadherinMouth MucosaE-cadherinMiddle Agedmedicine.diseaseCadherinsEpitheliummedicine.anatomical_structurecadherinCase-Control StudiesFemaleInternational journal of immunopathology and pharmacology
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Mycophenolate mofetil and enteric-coated mycophenolate sodium in the treatment of pemphigus vulgaris and pemphigus foliaceus.

2014

What is known and objective: Pemphigus is a severe, potentially life-threatening autoimmune blistering disease. The use of corticosteroids has dramatically improved the prognosis and changed its course. However, current morbidity of pemphigus is largely iatrogenic, caused by side effects of the long-term, high-dose corticosteroid therapy that is necessary to sustain disease control. In order to minimize side effects, a range of corticosteroid-sparing immunosuppressive agents have been introduced, including mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS). A systematic review was performed to evaluate the effectiveness of MMF and EC-MPS in the treatment of pemphig…

medicine.medical_specialtyEnteric-coated mycophenolate sodium mycophenolate mofetil mycophenolic acid pemphigus foliaceus pemphigus vulgaris therapyDermatologyMycophenolateMycophenolic acidimmune system diseasesmedicineSettore MED/35 - Malattie Cutanee E VenereeHumansEnteric coatedskin and connective tissue diseasesGlucocorticoidsPemphigus foliaceusintegumentary systembusiness.industryPemphigus vulgarisMycophenolate SodiumMycophenolic AcidPrognosismedicine.diseaseDermatologyPemphigusTreatment OutcomeDrug Therapy CombinationDermatologic AgentsbusinessImmunosuppressive AgentsPemphigusmedicine.drugBlistering disease
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Pharmacokinetic evaluation of mycophenolate mofetil for pemphigus.

2011

Introduction: Pemphigus is an autoimmune blistering disease of the skin and mucous membranes characterized by the development of autoantibodies against the desmosomal proteins, desmoglein-1 and -3. Before the advent of corticosteroids, therapy was almost fatal. The introduction of high-dose corticosteroid therapy has reduced mortality rates to similar to 10%, but long-term use of steroids can lead to side effects, many of which are severe and associated with significant morbidity. Thus, the major goal of pemphigus therapy has been to reduce the patient's cumulative exposure to systemic corticosteroids. Over the last 2 decades, a range of corticosteroid-sparing immunosuppressive agents have …

medicine.medical_specialtyToxicologyMycophenolateMycophenolic acidPharmacokineticsAdrenal Cortex HormonesmedicineInitial treatmentimmunosuppressant inosine monophosphate dehydrogenase mycophenolate mofetil mycophenolic acid pemphigus pharmacokinetic treatmentHumansPharmacologyintegumentary systembusiness.industryMortality rateAutoantibodyGeneral MedicineMycophenolic Acidmedicine.diseaseDermatologyPemphigusImmunologybusinessImmunosuppressive AgentsPemphigusmedicine.drugBlistering diseaseExpert opinion on drug metabolismtoxicology
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